A membrana plasmática não isola totalmente a célula do meio que a envolve. Ela precisa, para se manter viva, absorver substâncias e eliminar os resíduos de seu metabolismo. A membrana possui, portanto, uma permeabilidade seletiva, exercendo um controle sobre as substâncias que devem entrar ou sair dela.
O fluxo das substâncias através da membrana plasmática pode envolver ou não gastos de energia. Quando a membra permite a livre passagem das substâncias, sem haver consumo energético, ocorre um transporte passivo. Quando o transporte ocorre na presença de carregadores específicos, com gasto energético por parte da célula, é chamado transporte ativo.
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